Nature Communications · 2014 · 229 citations · 47 references
Life SciencesMolecular BiologyMolecular MedicineGene ExpressionInflammationVascular SurgeryAortic DiseaseCardiovascular DiseaseInflammatory MediatorsInflammatory SignalingMicrorna BiologyMicrorna-mediated RegulationCardiovascular BiologyCellular Adhesion Molecule ExpressionCytokine SynthesisInflammatory Cytokine ProductionMacrophage Cytokine ProductionMicrorna BiomarkersMicrorna Gene RegulationMicrorna Regulation Of Inflammation
Identification and treatment of abdominal aortic aneurysm (AAA) remain among the most prominent challenges in vascular medicine. MicroRNAs (miRNAs) are crucial regulators of cardiovascular pathology and represent intriguing targets to limit AAA expansion. Here we show, by using two established murine models of AAA disease along with human aortic tissue and plasma analysis, that miR-24 is a key regulator of vascular inflammation and AAA pathology. In vivo and in vitro studies reveal chitinase 3-like 1 (Chi3l1) to be a major target and effector under the control of miR-24, regulating cytokine synthesis in macrophages as well as their survival, promoting aortic smooth muscle cell migration and cytokine production, and stimulating adhesion molecule expression in vascular endothelial cells. We further show that modulation of miR-24 alters AAA progression in animal models, and that miR-24 and CHI3L1 represent novel plasma biomarkers of AAA disease progression in humans.
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In silico prediction of protein-protein interactions in human macrophages
Oussema Souiai, Fatma Z. Guerfali, Slimane Ben Miled et al. · BMC Research Notes · 2014 · 11K citations · Full text
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