Detection of a Hodgkin/Reed‐Sternberg cell specific immunoglobulin gene rearrangement in the serum DNA of a patient with Hodgkin's disease

Abstract

We analysed multiple serum samples from a patient with mixed cellularity Hodgkin's disease for the Hodgkin/Reed-Sternberg cell clone-specific rearranged Ig gene sequence. The clone-specific sequence could be detected in DNA extracted from a serum sample obtained during clinical relapse but not in serum samples obtained during or after treatment following relapse.