Pericarditis in a Case of Early Daunorubicin Cardiomyopathy

Abstract

Letters1 September 1976Pericarditis in a Case of Early Daunorubicin CardiomyopathyDAVID T. HARRISON, M.D., LEE A. SANDERS, M.D., PH.D.DAVID T. HARRISON, M.D., LEE A. SANDERS, M.D., PH.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-85-3-339 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe anthracycline antibiotics, daunorubicin and adriamycin, may both produce serious cardiac toxicity (1, 2). Cardiomyopathy appearing within months of a cumulativedose of daunorubicin exceeding 750 mg/m2 body surface was initially described. The cardinal features were cardiomegaly with biventricular failure and reduced electrocardiogram (ECG) voltage variably responsive to medical therapy. Subsequently the syndrome was observed after smaller doses, and fulminant cardiovascular collapse was described. We witnessed such a case 6 days after a total daunorubicin course of 210 mg/m2 body surface where pericarditis heralded the cardiac toxicity.A 41-year-old woman was referred for treatment of recently...References1. HALAZUNWAGNERGAETA JHJ: Daunorubicin cardiac toxicity in children with acute lymphocytic leukemia. Cancer 33:545-554, 1974 CrossrefMedlineGoogle Scholar2. LEFRAKPITHAROSENHEIM EJS: A clinicopathologic analysis of adriamycin cardiotoxicity. Cancer 32:302-314, 1973 CrossrefMedlineGoogle Scholar3. BONADONNAMONFARDINIGUINDANI GSA: Terapia con daunomicina nelle malattie linfoproliferative croniche. Tumori 54:465-481, 1968 CrossrefMedlineGoogle Scholar4. BONADONNAMONFARDINI GS: Cardiac toxicity of daunorubicin (letter). Lancet 1:837, 1969 CrossrefMedlineGoogle Scholar5. EDITORIAL: Daunorubicin and the heart. Br Med J 2:431-432, 1974 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Departments of Medicine and Pathology University of Washington School of Medicine Seattle, WA 98195 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAge-Related Considerations in Cardio-OncologyChildhood cancer survivors: The integral role of the cardiologist and cardiovascular imagingCardiotoxicityChemotherapy-Associated ArrhythmiasSynthetic analog of anticancer drug daunorubicin from daunorubicinone using one-pot enzymatic UDP-recycling glycosylationCardiotoxicitySchwere, allgemeine VasospasmophilieANTHRACYCLINE CARDIOTOXICITY IN CHILDHOODAnthracycline cardiotoxicityPathology of radiation and anthracycline cardiotoxicityKardiotoxizit�t von 5-FlurouracilCardiotoxicity of Chemotherapeutic AgentsDoxorubicin-Induced CardiomyopathyKlinik der KardiomyopathienPlasma endothelin-1 As a marker for doxorubicin cardiotoxicityPericarditis Associated with High-Dose Cytarabine Therapy for Acute Myeloblasts Leukemia: a Rare Complication of TherapyAcute Cardiotoxicity After Daunorubicin in Acute Myeloid LeukaemiaKlinik der KardiomyopathienMyokarderkrankungenClinical Presentations of Doxorubicin-Induced CardiotoxicityClinical and morphologic cardiac findings after anthracycline chemotherapyDilated Cardiomyopathies of the AdultDoxorubicin cardiotoxicityKlinik der MyokardiopathienEarly anthracycline cardiotoxicity 1 September 1976Volume 85, Issue 3Page: 339-341KeywordsAntibioticsAtrophyCardiomyopathiesEdemaElectrocardiographyMyocardiumNecrosisToxicity Issue Published: 1 September 1976 PDF DownloadLoading ...