Synthesis of [1,2,4]triazolo[3,4‐<i>b</i>][1,3]thiazine‐5‐carboxylates <i>via</i> one‐pot reaction of <i>N</i>‐substituted‐hydrazino‐carbothioamides with diethyl maleate

Abstract

Abstract magnified image Diethyl maleate reacts with N ‐substituted‐hydrazino‐carbothioamides to form ethyl [1,2,4]triazolo[3,4‐ b ][1,3]thiazine‐5‐carboxylates. Reaction proceeds via bicyclization and oxidation processes. J. Heterocyclic Chem. (2009).