Experimental & Molecular Medicine · 2003 · 11 citations · 1 references
Life SciencesChemistryMolecular BiologyBiophysical ChemistryNucleic Acid BiochemistryNucleic Acid ChemistryDna ChemistryDna CrosslinkingDna StabilityDna StructureAbsorbance SpectroscopyCoil-to-helix TransitionCovalent InteractionsDna Melting TemperatureDna ThermodynamicsHelix-coil TransitionMelting Temperature AnalysisPh Effects On Dna Stability
The peculiarities of helix-coil transition of DNA at complex-formation with cis-diamminedichlorplatinum (II) (cis-DDP) have been investigated in acidic environment by UV absorbance technique. It is shown that observed features of behavior T (pH) and T(m) (pH) DNA at pH 2.8-3.0 are possible to explain by formation in DNA of pseudo-ring structures at covalent linking of cis-DDP with DNA.
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