Tramadol increases extracellular levels of serotonin and noradrenaline as measured by in vivo microdialysis in the ventral hippocampus of freely-moving rats

The rat brain in stereotaxic coordinates

Miklós Palkovits · Neuropeptides · 1983 · 29K citations

Medicine, Neurobiology, Neuroscience +12

Comparative Affinity of Duloxetine and Venlafaxine for Serotonin and Norepinephrine Transporters in vitro and in vivo, Human Serotonin Receptor Subtypes, and Other Neuronal Receptors

Frank P. Bymaster · Neuropsychopharmacology · 2001 · 720 citations · Full text

Medicine, Neuroscience, Pharmacology +17

(–)-(1 R,2 R)-3-(3-Dimethylamino-1-ethyl-2-methyl-propyl)-phenol Hydrochloride (Tapentadol HCl): a Novel μ-Opioid Receptor Agonist/Norepinephrine Reuptake Inhibitor with Broad-Spectrum Analgesic Properties

Thomas Tzschentke, Thomas Christoph, Babette Kögel et al. · Journal of Pharmacology and Experimental Therapeutics · 2007 · 394 citations

Medicine, Pharmacology, Pharmacotherapy +16

Interaction of the central analgesic, tramadol, with the uptake and release of 5‐hydroxytryptamine in the rat brain <i>in vitro</i>

Bernd Driessen, Wolfgang Reimann · British Journal of Pharmacology · 1992 · 243 citations · Full text

Medicine, Neuroscience, Pharmacology +17

Contribution of monoaminergic modulation to the analgesic effect of tramadol

Jules Desmeules, Valérie Piguet, L Collart et al. · British Journal of Clinical Pharmacology · 1996 · 240 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +17