Analytical Chemistry · 1996 · 52 citations · 20 references
Natural SciencesChemistryAnalytical ChemistryMass Spectrometric AnalysisPolymer ChemistryAerosol ChemistryAerosol ScienceChromatographyMass SpectrometryPeptide AnalysisPolymer AnalysisAerosol Mass SpectrometryMatrix-assisted Laser Desorption Ionization Time-of-flight Mass SpectrometryMatrix-assisted Laser Desorption/ionizationMatrix-assisted Laser Desorption/ionization Time-of-flight Mass SpectrometryPolymer Mass SpectrometryPolymer Matrix-assisted Laser Desorption/ionizationSynthetic PolymersTime-of-flight Mass Spectrometry
Gel permeation chromatography (GPC) was combined directly with aerosol matrix-assisted laser desorption/ionization (MALDI) mass spectrometry for the analysis of synthetic polymers. In the aerosol MALDI/GPC-MS experiment, effluent from the GPC column was combined with matrix solution and sprayed directly into a time-of-flight mass spectrometer (TOF-MS). Ions were formed by irradiation of the aerosol particles with pulsed 355 nm radiation from a frequency-tripled Nd:YAG laser. The ions were mass separated in a two-stage reflectron TOF-MS, and averaged mass spectra were stored every 11 s throughout the GPC-MS experiment. On-line GPC/MALDI-MS was performed with the commercially available polymers poly(ethylene glycol) (PEG 1000) and poly(propylene glycol) (PPG 1000).
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Keith Brown, Susan M. Gerstberger, Louise Carlson et al. · Science · 1995 · 1.4K citations