Oncology · 2009 · 724 citations · 0 references
MedicineGeneticsOncologyMolecular OncologyMolecular PathologyNeoplasiaCancer Genomic InstabilityCancer Molecular PathologyCirculating Tumor Dna AnalysisMalignant NeoplasmsCirculating Cell-free Dna AnalysisCirculating Tumor Dna DetectionCirculating Tumor Dna TestingNeoplastic Disease
About one third of patients with various malignant diseases were found to have extractable amounts of DNA in their plasma whereas no DNA could be detected in normal controls. Using the test established by one of us (M.B.), which is based on decreased strand stability of cancer cell DNA, we have found that several plasma DNA originate from cancer cells.