Imprinted tumor suppressor genes <i>ARHI</i> and <i>PEG3</i> are the most frequently down‐regulated in human ovarian cancers by loss of heterozygosity and promoter methylation

Abstract

Loss of expression of the growth-inhibitory imprinted genes ARHI and PEG3 through promoter methylation, LOH, and other mechanisms may stimulate clonogenic growth and contribute to the pathogenesis of a majority of ovarian cancers.