In vitro establishment of cis-diammine-dichloroplatinum(II) resistant lung cancer cell line and modulation of apoptotic gene expression as a mechanism of resistant phenotype

DNA Damage-Induced Activation of p53 by the Checkpoint Kinase Chk2

Atsushi Hirao, Young‐Yun Kong, Shuhei Matsuoka et al. · Science · 2000 · 1.3K citations

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Modulation of Activity of the Promoter of the Human <i>MDR</i> 1 Gene by Ras and p53

Khew‐Voon Chin, Kazumitsu Ueda, Ira Pastan et al. · Science · 1992 · 731 citations

Medicine, Molecular Genetics, Oncology +17

Association between cisplatin resistance and mutation of p53 gene and reduced bax expression in ovarian carcinoma cell systems.

Paola Perego, Monica Giarola, Sabina Carla Righetti et al. · PubMed · 1996 · 393 citations

Medicine, Genetics, Oncology +16

Cisplatin-induced apoptosis proceeds by caspase-3-dependent and -independent pathways in cisplatin-resistant and -sensitive human ovarian cancer cell lines.

Karen M. Henkels, John J. Turchi · PubMed · 1999 · 240 citations

Medicine, Oncology, Pharmacology +17

Increased accumulation of p53 protein in cisplatin‐resistant ovarian cell lines

Robert Brown, Carol K. Clugston, A Edlin et al. · International Journal of Cancer · 1993 · 205 citations

Medicine, Cancer Biology, Molecular Biology +16