Inhibition of the Na+/H+ exchanger attenuates phase 1b ischemic arrhythmias and reperfusion-induced ventricular fibrillation

Role of intracellular Na+ in Ca2+ overload and depressed recovery of ventricular function of reperfused ischemic rat hearts. Possible involvement of H+-Na+ and Na+-Ca2+ exchange.

M Tani, J. R. Neely · Circulation Research · 1989 · 758 citations

Medicine, Cardiology, Physiology +11

Molecular cloning of putative members of the Na/H exchanger gene family. cDNA cloning, deduced amino acid sequence, and mRNA tissue expression of the rat Na/H exchanger NHE-1 and two structurally related proteins.

John Orlowski, Ramani A. Kandasamy, Gary E. Shull · Journal of Biological Chemistry · 1992 · 589 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +13

Protective effects of HOE642, a selective sodium-hydrogen exchange subtype 1 inhibitor, on cardiac ischaemia and reperfusion

W. Scholz, Udo Albus, Laurent Counillon et al. · Cardiovascular Research · 1995 · 418 citations

Medicine, Cardiology, Pharmacology +7

Release of endogenous catecholamines in the ischemic myocardium of the rat. Part A: Locally mediated release.

Albert Schömig, Anthony M. Dart, Rainer Dietz et al. · Circulation Research · 1984 · 366 citations · Full text

Life Sciences, Cardiology, Physiology +5

Correlation between cytosolic free calcium, contracture, ATP, and irreversible ischemic injury in perfused rat heart.

Charles Steenbergen, Elizabeth W. Murphy, John A. Watts et al. · Circulation Research · 1990 · 364 citations · Full text

Life Sciences, Biochemistry, Physiology +13