Effect of Lifestyle Changes on Erectile Dysfunction in Obese Men

TLDR

Healthy lifestyle factors are linked to the preservation of erectile function in men. The study aimed to assess whether weight loss and increased physical activity improve erectile and endothelial function in obese men. A randomized, single‑blind trial of 110 obese men (BMI ≥ 30) aged 35‑55 without diabetes, hypertension, or hyperlipidemia compared a structured 10 % weight‑loss and exercise program to general health advice over two years. The intervention produced significant weight loss, reduced inflammatory markers, increased physical activity, and improved erectile function, with about one‑third of participants achieving IIEF scores ≥ 22, and BMI, activity, and CRP changes independently predicted IIEF improvement.

Abstract

Healthy lifestyle factors are associated with maintenance of erectile function in men.To determine the effect of weight loss and increased physical activity on erectile and endothelial functions in obese men.Randomized, single-blind trial of 110 obese men (body mass index > or =30) aged 35 to 55 years, without diabetes, hypertension, or hyperlipidemia, who had erectile dysfunction that was determined by having a score of 21 or less on the International Index of Erectile Function (IIEF). The study was conducted from October 2000 to October 2003 at a university hospital in Italy.The 55 men randomly assigned to the intervention group received detailed advice about how to achieve a loss of 10% or more in their total body weight by reducing caloric intake and increasing their level of physical activity. Men in the control group (n = 55) were given general information about healthy food choices and exercise.Erectile function score, levels of cholesterol and triglycerides, circulating levels of interleukin 6, interleukin 8, and C-reactive protein, and endothelial function as assessed by vascular responses to l-arginine.After 2 years, body mass index decreased more in the intervention group (from a mean [SD] of 36.9 [2.5] to 31.2 [2.1]) than in the control group (from 36.4 [2.3] to 35.7 [2.5]) (P<.001), as did serum concentrations of interleukin 6 (P =.03), and C-reactive protein (P =.02). The mean (SD) level of physical activity increased more in the intervention group (from 48 [10] to 195 [36] min/wk; P<.001) than in the control group (from 51 [9] to 84 [28] min/wk; P<.001). The mean (SD) IIEF score improved in the intervention group (from 13.9 [4.0] to 17 [5]; P<.001), but remained stable in the control group (from 13.5 [4.0] to 13.6 [4.1]; P =.89). Seventeen men in the intervention group and 3 in the control group (P =.001) reported an IIEF score of 22 or higher. In multivariate analyses, changes in body mass index (P =.02), physical activity (P =.02), and C-reactive protein (P =.03) were independently associated with changes in IIEF score.Lifestyle changes are associated with improvement in sexual function in about one third of obese men with erectile dysfunction at baseline.