4beta-hydroxycholesterol as a marker of CYP3A4 inhibition in vivo – effects of itraconazole in man - Concepedia

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4beta-hydroxycholesterol as a marker of CYP3A4 inhibition in vivo – effects of itraconazole in man

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References

2009

Year

Dieter Lütjohann, Milka Marinova, Bianca E. Schneider, Johannes Oldenburg, K. von Bergmann, Theodore I. Bieber, Ingemar Björkhem, Ulf Diczfalusy

International Journal of Clinical Pharmacology and Therapeutics

Abstract

In conclusion, 4beta-hydroxycholesterol appears to be a sensitive endogenous surrogate marker in human serum for inhibition of CYP3A4 by itraconazole.