Superior Angiogenic Potential of GDF-5 and GDF-5V453/V456 Compared with BMP-2 in a Rabbit Long-Bone Defect Model

Abstract

Although both BMP-2 and the GDF-5 variant BB-1 are good inducers of bone formation, BB-1 is especially promising for long-bone healing if high angiogenicity is desired along with high osteogenicity to promote recreation of optimal bone architecture.