Innervation of the Lumbar Intervertebral Disc by Nerve Growth Factor-Dependent Neurons Related to Inflammatory Pain

Abstract

We found that most small neurons innervating the disc were CGRP-ir. Furthermore, disc inflammation caused an increase in CGRP-ir neurons but not IB4-binding neurons, suggesting that CGRP-ir, nerve growth factor-dependent neurons are more responsible for discogenic pain.