Suppressor mononuclear cells in giant lymph node hyperplasia and thymoma

Abstract

The existence of suppressor mononuclear cells were demonstrated in two lymphoproliferative disorders: giant lymph node hyperplasia and thymona. The three patients tested also showed cell-mediated immunodeficiency as expressed in the low number of T cells, negative graft versus host reactions and negative skin tests; the one patient tested with phytohemagglutinin (PHA) and concavalin A (Con A) showed a low response. Suppressor activity was tested with a new experimental model, the local xenogeneic graft versus host reaction. It is proposed that this model be used for testing suppressor activities in other human disorders as well.