Aging stimulates cyclooxygenase‐2 expression and prostaglandin E₂ production in human periodontal ligament cells after the application of compressive force

Abstract

Periodontal ligament cells obtained from old donors have significantly greater COX-2 expression and PGE2 production in response to compressive force than those from younger donors. The turning point of aging, where significantly larger amounts of theses factors begin production, appears to be around the age of 35. These results may be positively related to the acceleration of alveolar crestal bone loss during orthodontic treatment in adult patients.