Gene expression changes in rat liver following exposure to liver growth agents: role of Kupffer cells in xenobiotic-mediated liver growth

Role of the Ubiquitin-Proteasome Pathway in Regulating Abundance of the Cyclin-Dependent Kinase Inhibitor p27

Michele Pagano, Sun W. Tam, Anne M. Theodoras et al. · Science · 1995 · 1.8K citations

Life Sciences, Cell Biology, Molecular Biology +16

Targeted Disruption of the α Isoform of the Peroxisome Proliferator-Activated Receptor Gene in Mice Results in Abolishment of the Pleiotropic Effects of Peroxisome Proliferators

Susanna S.T. Lee, Thierry Pineau, John Drago et al. · Molecular and Cellular Biology · 1995 · 1.6K citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +16

Hypolipidaemic hepatic peroxisome proliferators form a novel class of chemical carcinogens

Janardan K. Reddy, Daniel L. Azarnoff, Charles E. Hignite · Nature · 1980 · 844 citations

Pharmacy, Pharmacology, Toxicology +16

Controlled death (apoptosis) of normal and putative preneoplastic cells in rat liver following withdrawal of tumor promoters

Wilfried Bursch, B. Lauer, I. Timmermann-Trosiener et al. · Carcinogenesis · 1984 · 366 citations

Medicine, Oncology, Pharmacology +12

Relationship of hepatic peroxisome proliferation and replicative DNA synthesis to the hepatocarcinogenicity of the peroxisome proliferators di(2-ethylhexyl)phthalate and [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid (Wy-14,643) in rats.

Daniel S. Marsman, Russell C. Cattley, James G. Conway et al. · PubMed · 1988 · 356 citations

Pharmacy, Toxicology, Carcinogenesis +15