Optimal control of tumor size used to maximize survival time when cells are resistant to chemotherapy

Applied Optimal Control

J. E. J. · Technometrics · 1979 · 3.1K citations

A mathematic model for relating the drug sensitivity of tumors to their spontaneous mutation rate.

Goldie Jh, Coldman Aj · PubMed · 1980 · 1.3K citations

Medicine, Cancer Biology, Oncology +16

Cancer: Principles and Practice of Oncology.

Annals of Internal Medicine · 1986 · 1.1K citations

Medicine, Oncology, Oncology Nursing +10

Rationale for the use of alternating non-cross-resistant chemotherapy.

Goldie Jh, Coldman Aj, Gudauskas Ga · PubMed · 1982 · 550 citations

Medicine, Oncology, Pharmacology +10

On Certain Questions in the Theory of Optimal Control

Alexander Filippov · Journal of the Society for Industrial and Applied Mathematics Series A Control · 1962 · 441 citations

Natural Sciences, Mathematics, Dynamical Systems +16