Protective Role of Methionine Sulfoxide Reductase A Against Ischemia/Reperfusion Injury in Mouse Kidney and Its Involvement in the Regulation of Trans-Sulfuration Pathway

Abstract

Our data demonstrate that MsrA protects the kidney against I/R injury, and that this protection is associated with reduced oxidative stress and inflammatory responses. The data indicate that MsrA regulates H(2)S production during I/R by modulating the expression and activity of the CBS and CSE enzymes.