Aldose reductase regulates TGF‐β1‐induced production of fibronectin and type IV collagen in cultured rat mesangial cells

Abstract

AR can regulate the expression of fibronectin and type IV collagen with the stimulation of TGF-beta1 in MsC, which may have relations with the activation of JNK-MAPK and p38-MAPK signalling pathways and AP-1.