Omega‐3 fatty acid supplementation reduces tumor growth and vascular endothelial growth factor expression in a model of progressive non‐metastasizing malignancy

Abstract

These data demonstrate that EPA supplementation inhibits tumor growth, potentially through alterations in the expression of the pro-angiogenic VEGF-alpha. The mechanism(s) of EPA as an inhibitor of tumor-related angiogenic growth factors may be associated with COX-2 enzyme fatty acid metabolism and merits further study.