A migrating group in a glutamate mutase model reaction mediated by a functionalised bilayer membrane

Abstract

The alkylated hydrophobic vitamin B12, prepared by the reaction of heptapropyl cobyrinate with diethyl β-bromomethyl-β-deuterio-DL-aspartate, affords diethyl γ-deuterioglutamate, the glycyl-migrated product, in the single-compartment vesicle of N,N-dihexadecyl-Nα-[6-(trimethylammonio)hexanoyl]-L-alaninamide bromide under anaerobic photolysis conditions.