Increased Bleeding Tendency and Decreased Susceptibility to Thromboembolism in Mice Lacking the Prostaglandin E Receptor Subtype EP <sub>3</sub> - Concepedia

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Increased Bleeding Tendency and Decreased Susceptibility to Thromboembolism in Mice Lacking the Prostaglandin E Receptor Subtype EP <sub>3</sub>

109

Citations

27

References

2001

Year

Hong Ma, Akiyoshi Hara, Chun Xiao, Yuji Okada, Osamu Takahata, Kazuhiro Nakaya, Yukihiko Sugimoto, Atsushi Ichikawa, Shuh Narumiya, Fumitaka Ushikubi

Abstract

- PGE(2) potentiated platelet aggregation induced by U46619 via EP(3) by increasing [Ca(2+)](i), decreasing [cAMP](i), or both. This potentiating action of PGE(2) via EP(3) is essential in mediating both physiological and pathological effects of PGE(2) in vivo.

References

	Year	Citations

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