A Comparison of the Effects of Propofol and Sevoflurane on the Systemic Toxicity of Intravenous Bupivacaine in Rats

Abstract

In anesthetized patients, dysrhythmias may be the only warning sign of intravascular injection of bupivacaine. Because propofol has a wider margin of safety than sevoflurane, life-threatening cardiovascular depression may be prevented by stopping the injection of bupivacaine at the onset of dysrhythmias during propofol anesthesia.