Characterization of Rhodopsin P23H-Induced Retinal Degeneration in a<i>Xenopus laevis</i>Model of Retinitis Pigmentosa

Abstract

These results support a role for rhoP23H misfolding and inner segment accumulation in rod death, possibly by ER overload or other cellular stress pathways rather than by altered rhodopsin signal transduction or aggresome formation.