One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Using ZnCl2, CuCl2, NiCl2 and CoCl2 Doped Hydroxyapatite

Abstract

Hydroxyapatite doped with ZnCl2, CuCl2, NiCl2 and CoCl2 efficiently catalyses the three components Biginelli reaction between an aldehyde, ethyl acetoacetate and urea in refluxing toluene to afford the corresponding dihydropyrimidinones in high yields. Keywords: biginelli reaction, heterogeneous catalysis, dihydropyrimidinones, hydroxyapatite, lewis acids