The HLA A1‐B8 haplotype extends 6 Mb beyond HLA‐A: associations between HLA‐A, B, F and 15 microsatellite markers

Abstract

Allele frequencies for HLA‐A, B and F and 15 microsatellite markers located from 100 kb telomeric to HLA‐A to 6 Mb telomeric have been determined in a group of 60 blood donors. Linkage disequilibrium analysis revealed significant haplotype associations even after correction for the number of comparisons made. The HLA‐A1, B8 haplotype extends as far as D6S276 (6.0 Mb telomeric to HLA‐A). It is important to realize that this common haplotype extends beyond the HLA region, especially when evaluating haplotype associations with particular disorders.