THR (Lopremone): Psychobiological Responses of Normal Women

Abstract

Ten normal women were injected intravenously with lopremone (thyrotropin releasing hormone) and saline given one to four weeks apart in a double-blind study. After saline, somatic symptoms and mental changes were negligible. After lopremone, subjects experienced a variety of somatic symptoms, usually within a few minutes of injection. Later they experienced relaxation, mild euphoria, and a sense of increased energy. Since correlation analyses showed that intensity of euphoria was not related to frequency of side-effects and was negatively related to magnitude of thyrotropin (thyroid stimulating hormone, TSH) response, euphoria presumably did not arise solely from suggestion or from thyroid stimulation.