Inactivation of p16INK4a expression in malignant mesothelioma by methylation

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.

James G. Herman, Jeremy R. Graff, Sanna Myöhänen et al. · Proceedings of the National Academy of Sciences · 1996 · 5.7K citations

Life Sciences, Genetics, Molecular Biology +17

A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types

Alexander Kamb, Nelleke A. Gruis, Jane Weaver-Feldhaus et al. · Science · 1994 · 2.8K citations

Life Sciences, Genetics, Molecular Genetics +17

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

Dawn E. Ouelle, Frédérique Zindy, Richard A. Ashmun et al. · Cell · 1995 · 1.5K citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers.

James G. Herman, Adrian Merlo, Li Mao et al. · PubMed · 1995 · 1.4K citations

Medicine, Genetics, Oncology +17

Aberrant methylation of <i>p16</i> ^INK4a is an early event in lung cancer and a potential biomarker for early diagnosis

Steven A. Belinsky, Kristen J. Nikula, William A. Palmisano et al. · Proceedings of the National Academy of Sciences · 1998 · 962 citations · Full text

Medicine, Genetics, Molecular Biology +17