Immunization of Mice with Polysaccharides of Histoplasma capsulatum.

Abstract

SummaryH. capsulatum strain G17 (M) polysaccharide was capable of producing active resistance against intravenously induced histoplasmosis in mice. However, mice immunized with a H. capsulatum whole yeast cell antigen showed greater resistance when the H. capsulatum polysaccharide immunized, whole cell immunized and nonimmunized control mice were challenged by the intravenous injection of known numbers of viable H. capsulatum yeast phase organism.