Increased Excitability and Decreased Sensitivity to GABA in an Animal Model of Dysplastic Cortex

Abstract

BCNU exposure in utero produces histologic alterations suggestive of CD in rat offspring. Dysplastic cortex from this model demonstrates features of hyperexcitability and decreased neuronal sensitivity to GABA. Such physiologic alterations may underlie the increased epileptogenicity of dysplastic cortex.