A novel <i>N</i>‐ethyl‐<i>N</i>‐nitrosourea–induced mutation in <i>phospholipase Cγ2</i> causes inflammatory arthritis, metabolic defects, and male infertility in vitro in a murine model

Abstract

These results suggest that the Plcg2-mediated pathways play a crucial role in various metabolic and sperm functions, in addition to initiating and maintaining the immune system. These findings may indicate the importance of the Ali14/+ mouse strain as a model for systemic inflammatory diseases and inflammation-related metabolic changes in humans.