The Use of Polymer Heteronuclei for Crystalline Polymorph Selection

Abstract

A method for the production of crystalline polymorphs from solution is described which utilizes a diverse set of polymer heteronuclei. Application to crystalline polymorph selection for the important pharmaceuticals acetaminophen and carbamazepine is demonstrated. This method provides a new paradigm for polymorph selection, where solvent and temperature conditions can be chosen on the basis of process considerations and the polymer heteronucleus can be varied for specific polymorph production.