Tetracyclic benzodiazepines. 4. Synthesis of the novel benzo[<i>c</i>]pyrrolo[1,2,3‐<i>ef</i>][1,5]benzodiazepine ring system, and derivatives with potential antipsychotic activity

Abstract

Abstract The synthesis of the novel benzo[ c ]pyrrolo[1,2,3‐ ef ][1,5]benzodiazepine ring system is described. This was achieved by cyclization of an appropriately substituted (7‐aminoindolin‐1‐yl)benzamide or benzoic acid. The resulting tetracyclic lactams were reacted with N ‐methylpiperazine in the presence of titanium tetrachloride to provide derivatives which were tested for potential antipsychotic activity.