Long-term Antibiotic Therapy in Tropical Sprue

Abstract

Article1 October 1965Long-term Antibiotic Therapy in Tropical SprueRICARDO GUERRA, M.D., MUNSEY S. WHEBY, THEODORE M. BAYLESS, M.D.RICARDO GUERRA, M.D.Search for more papers by this author, MUNSEY S. WHEBYSearch for more papers by this author, THEODORE M. BAYLESS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-4-619 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe etiology and pathogenesis of tropical sprue are still unknown. The intestinal malabsorption that characterizes this disease is associated with alterations in the small intestinal mucosa. Folic acid deficiency is not believed to be the cause of these lesions, but folic acid (1) or vitamin B12 (2, 3) therapy usually results in rapid clinical improvement, hematologic remission, and some decreases in the jejunal abnormalities. However, in spite of this therapy, malabsorption continues in at least two thirds of the patients (4), and some remain incapacitated.An infectious cause of tropical sprue has been suspected, but no etiologic agent has been...References1. DARBYJONES WJE: Treatment of sprue with synthetic L. casei factor (folic acid, vitamin M). Proc. Soc. Exp. Biol. Med. 60: 259, 1945. CrossrefMedlineGoogle Scholar2. SPIESSUAREZ TDRM: Response of tropical sprue to vitamin B12. Blood 3: 1213, 1948. CrossrefMedlineGoogle Scholar3. SUAREZSPIESHERNANDEZ-MORALESPEREZ-SANTIAGO RMTDFE: Note on effectiveness of vitamin B12 in treatment of tropical sprue in relapse. Blood 4: 1124, 1949. CrossrefMedlineGoogle Scholar4. SHEEHYBAGGSPEREZ-SANTIAGOFLOCH TWBEMH: Prognosis of tropical sprue. A study of the effect of folic acid on the intestinal aspects of acute and chronic sprue. Ann. Intern. Med. 57: 892, 1962. LinkGoogle Scholar5. NADELGARDNER HFN: Bacteriological assay of small bowel secretion in tropical sprue. Amer. J. Trop. Med. Hyg. 5: 686, 1956. CrossrefMedlineGoogle Scholar6. WHEBYBAYLESSGUARDIOLA MSTMA: Discussion conference on intestinal malabsorption and allied hematologic problems. Amer. J. Dig. Dis. 9: 806, 1964. Google Scholar7. FRENCHGADDIESMITH JMRNM: Tropical sprue. A study of seven cases and the response to combined chemotherapy. Quart. J. Med. 49: 333, 1956. Google Scholar8. SHEEHYPEREZ-SANTIAGO TWE: Antibiotic therapy in tropical sprue. Gastroenterology 41: 208, 1961. CrossrefGoogle Scholar9. BUTTERWORTHPEREZ-SANTIAGO CEE: Jejunal biopsies in sprue. Ann. Intern. Med. 48: 8, 1958. LinkGoogle Scholar10. SWANSONTHOMASSEN VLRW: Pathology of the jejunal mucosa in tropical sprue. Amer. J. Path. 46: 511, 1965. MedlineGoogle Scholar11. BRECHERSCHNEIDERMANWILLIAMS GMAGZ: Evaluation of an electronic red cell counter. Amer. J. Clin. Path. 26: 1439, 1956. CrossrefMedlineGoogle Scholar12. CARRPRICE FHEA: Color reactions attributed to vitamin A. Biochem. J. 20: 497, 1926. CrossrefMedlineGoogle Scholar13. MARTINEZ-DE-JESUS J: Modification of Carr and Price method for carotene determination. Unpublished information. Google Scholar14. VAN DE KAMERTEN BOKKEL HUININKWEYERS JHHHA: A rapid method for the determination of fat in feces. J. Biol. Chem. 177: 347, 1949. CrossrefMedlineGoogle Scholar15. SANTINISHEEHYMARTINEZ-DE-JESUS RTWJ: The xylose tolerance test with a five-gram dose. Gastroenterology 40: 772, 1961. CrossrefMedlineGoogle Scholar16. CALDWELLSWANSONBAYLESS WLVLTM: Importance and reliability of the roentgenography examination of the small bowel in patients with tropical sprue. Radiology 84: 227, 1965. CrossrefMedlineGoogle Scholar17. HEINLEWELCHSCHARGMEACHAMPPRUSOFF RWADVGCWH: Studies of excretion (and absorption) of Co60-labeled vitamin B12 in pernicious anemia. Trans. Ass. Amer. Physicians 65: 214, 1952. MedlineGoogle Scholar18. SCHILLING RF: Intrinsic factor studies. II. The effect of gastric juice on the urinary excretion of radioactivity after the oral administration of radioactive vitamin B12. J. Lab. Clin. Med. 42: 860, 1953. MedlineGoogle Scholar19. DACIEWHITE JVJC: Erythropoiesis with particular reference to its study by biopsy of human bone marrow: a review. J. Clin. Path. 2: 1, 1949. CrossrefMedlineGoogle Scholar20. CANCIORODRIGUEZ-MOLINAASENJO MRCF: Gluten and tropical sprue. Amer. J. Trop. Med. 10: 782, 1961. CrossrefGoogle Scholar21. BAYLESS TM: Tropical sprue: a comparison with celiac disease. Amer. J. Dig. Dis. 9: 779, 1964. Google Scholar22. DONALDSON RM: Normal bacterial populations of the intestine and their relation to intestinal function. New Eng. J. Med. 270: 1050, 1964. CrossrefMedlineGoogle Scholar23. GUERRAWHEBY RMS: Unpublished observations. Google Scholar24. ABRAMSBAUERSPRINZ GDHH: Influence of normal flora on mucosal morphology and cellular renewal in the ileum. A comparison of germ-free and conventional mice. Lab. Invest. 12: 355, 1963. MedlineGoogle Scholar25. EYRSENDE SOMER HP: The mode of action of antibiotics in stimulating growth of chicks. J. Exp. Med. 117, 127, 1963. CrossrefMedlineGoogle Scholar26. BAYLESSGUARDIOLAWHEBY TMAMS: Viral cultures in tropical sprue. In preparation. Google Scholar27. MANSON-BAHR P: The causation of tropical sprue. Lancet 2: 389, 1953. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: San Juan, Puerto RicoFrom the U. S. Army Tropical Research Medical Laboratory, and the Department of Medicine, University of Puerto Rico School of Medicine, San Juan, Puerto Rico.This paper was presented in part at the Forty-fifth Annual Session of the American College of Physicians, Atlantic City, N. J., April 8, 1964.Requests for reprints should be addressed to Munsey S. Wheby, M.D., Department of Medicine, Rutgers Medical School, New Brunswick, N. J. 08903. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByInfections of the Gastrointestinal TractChronic Infections of the Small IntestineTropical SprueTropical Sprue in 2014: the New Face of an Old DiseaseGastrointestinal tractTropical SprueInfections of the Gastrointestinal TractTropical sprueTropical sprueTropical sprue is associated with contamination of small bowel with aerobic bacteria and reversible prolongation of orocecal transit timeA perspective on tropical sprueTropical Sprue and Subclinical Enteropathy: A Vision for the NinetiesCase 15-1990Tropische SprueIdiopathic Small Intestinal Disease in the TropicsTropical sprue in travelers and expatriates living abroadTropical Sprue: A ReviewAntimicrobial Therapy of Digestive DiseasesENTEROTOXIGENICITY OF COLONISING COLIFORM BACTERIA IN TROPICAL SPRUE AND BLIND-LOOP SYNDROMEContamination of the Small Intestine by Enterotoxigenic Coliform Bacteria among the Rural Population of HaitiFolic acid and hexose absorption in sprueEnterotoxigenic Intestinal Bacteria in Tropical SprueFREDERICK A. KLIPSTEIN, M.D., F.A.C.P., LILLIAN V. HOLDEMAN, Ph.D., JOSÉ J. CORCINO, M.D., W. E. C. MOORE, Ph.D.Tropical EnteropathyPublic Health Significance of Feeding Low Levels of Antibiotics to AnimalsMalabsorption syndromes in infancy and childhood. Part IIFolate in Tropical SprueVitamin B 12 and Tropical SprueClinical syndrome resembling tropical sprue in lifelong residents of temperate zoneLong-Term Follow-Up of Antibiotic-Treated Tropical SprueFREDERICK R. RICKLES, M.D., FREDERICK A. KLIPSTEIN, M.D., F.A.C.P., JUAN TOMASINI, M.D., JOSE J. CORCINO, M.D., NORMAN MALDONADO, M.D., F.A.C.P.Bacterial Flora of the Gastrointestinal Tract in Southern Indian Control Subjects and Patients with Tropical SprueIntestinal MicrofloraAn epidemic of tropical sprue in southern IndiaThe absorption and malabsorption of folic acid and its polyglutamatesRegarding the Definition of Tropical SprueTropical sprue in childrenPoorly Absorbed Sulfonamides in the Treatment of Tropical SprueTropical sprue.Treatment of overt and subclinical malabsorption in Haiti.Tropical Sprue in ChildrenMetabolism of Albumin and Fibrinogen in Patients with Tropical SprueBACTERIAL CONTAMINATION OF THE UPPER SMALL BOWEL IN TROPICAL SPRUECurrent Views on Tropical Sprue and a Comparison to Nontropical SprueJejunal Crypt Cell and Marrow Morphology in Tropical SprueMUNSEY S. WHEBY, M.D., F.A.C.P., VIRGINIA SWANSON, M.D., THEODORE M. BAYLESS, M.D., F.A.C.P.Persistent Deficiency of Intestinal Lactase in Apparently Cured Tropical SpruePotential Medical Problems in Personnel Returning from VietnamDAVID N. GILBERT, WILLIAM L. MOORE JR., CHARLES L. HEDBERG, JAY P. SANFORD, M.D., F.A.C.P.Tropical SprueIntestinal Disaccharidases in Tropical SprueCorrelation of Jejunal Function and Morphology in Patients with Acute and Chronic Diarrhea in East PakistanMalabsorption and Jejunitis in American Peace Corps Volunteers in PakistanJOHN LINDENBAUM, M.D., THOMAS H. KENT, M.D., HELMUTH SPRINZ, M.D., F.A.C.P.Folate Repletion Associated with Oral Tetracycline Therapy in Tropical SprueEffect of antibiotic therapy on gluten-sensitive enteropathyFlorid FloraTropical Sprue: Viral Cultures of Rectal Swabs 1 October 1965Volume 63, Issue 4Page: 619-634KeywordsAntibioticsExcretionFolic acidHematologic testsLesionsMucous membranesPathogenesisPatientsResearch laboratoriesVitamin E Issue Published: 1 October 1965 PDF DownloadLoading ...