Pigment Epithelium-Derived Factor Associates With Neuropathy and Fibrosis in Pancreatic Cancer

Abstract

PEDF increases PSC activity, thereby contributing to the desmoplasia of pancreatic cancer. PSC overactivation likely leads to periacinar fibrosis and degeneration of fine acinar innervation. Increased focal PEDF expression in cancer cells correlates with neuropathic changes and better patient survival.