The Effects of Ginsenoside Re and its Metabolite, Ginsenoside Rh1, on 12-<i>O</i>-Tetradecanoylphorbol 13-acetate- and Oxazolone-Induced Mouse Dermatitis Models

Abstract

The effects of the main constituent ginsenoside Re in ginseng and its metabolite, ginsenoside Rh1, were investigated in 12-O-tetradecanoylphorbol 13-acetate (TPA)- and oxazolone-induced mouse ear dermatitis models. Ginsenoside Rh1 potently suppressed the TPA- and oxazolone-induced swellings as well as mRNA expression levels of cyclooxygenase-2, IL-1beta and TNF-alpha, although these were only weakly inhibited by ginsenoside Re.