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THE HAEMOLYTIC ACTIVITY OF SOME FIBROUS AMPHIBOLES AND ITS RELATION TO THEIR SPECIFIC SURFACE AREAS
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1977
Year
BiochemistryMedicinePhysiologyBioanalysisPathologyFibre SurfaceElectrolyte DisturbanceChemical PathologyToxicologyHuman Serum AlbuminClinical ChemistrySpecific Surface AreaPharmacologyMineral MetabolismChromatographyExtracellular MatrixHealth Sciences
The haemolytic activities of a number of fibrous amphiboles, representing the five main types of this class of mineral, were measured. It was shown that there is a positive correlation between haemolytic activity and specific surface area. The mechanism of amphibole haemolysis is discussed and it is suggested that this is due to interaction between the fibre surface and proteins in the erythrocyte membrane. A positive correlation between haemolytic acitivity and adsorptive capacity for human serum albumin was demonstrated. The relationship between haemolytic activity and cytotoxicity measured in vitro and fibrogenicity measured in vivo is distfussed.