A Quantitative Histologic Analysis of Collagen Subtypes: The Primary Obstructed and Refluxing Megaureter of Childhood

Abstract

These data suggest that the greater contribution of type III collagen may play a role in the pathophysiology of refluxing megaureters. Because type III collagen is a less distensible fiber, it may cause an intrinsically stiffer ureter and play a role in the lower surgical success in the reimplantation of refluxing megaureters.