Suppression and Recovery of LPS-Stimulated Monocyte Activity After Trauma is Correlated With Increasing Injury Severity: A Prospective Clinical Study

Abstract

The extent of suppression of monocyte function is directly associated with the severity of trauma in both severely injured and patients with minor trauma. Acute posttraumatic changes in monocyte function and IL-6 concentrations were both predictive for the development of SIRS/sepsis. Although monocyte function in mildly injured patients is restored shortly after injury, the observed delay in recovery in severely traumatized patients may critically influence the clinical course.