Journal of Materials Chemistry · 2005 · 91 citations · 17 references
Natural SciencesBioengineeringMaterials ScienceBiomaterialsBone MetabolismTissue EngineeringBioceramicsBone TissueBone Tissue EngineeringCalcium Phosphate BiomaterialsRegenerative ScaffoldsTissue Engineering ScaffoldsCrystalline Phase FormationCrystalline Phase MorphologyHydroxyapatiteHydroxyapatite BiomaterialsHydroxyapatite Crystal FormationHydroxyapatite Crystal GrowthHydroxyapatite CrystallizationHydroxyapatite Scaffolds
Scaffolds of pure AB-type carbonated hydroxyapatite (HA) were successfully produced via hydrothermal transformation (HT) of aragonitic cuttlefish bones at 200 °C. Beyond low production cost, worldwide availability and natural biological origin of raw materials, the produced scaffolds preserved the initial structure of the cuttlefish bone, featuring pore size of ∼80 µm in width and ∼100 µm in height. The transformation was complete after 9 h and no intermediate products were registered. The kinetics were fast, since, HA was the dominant crystalline phase after only 1 h of HT. The HA crystallites formed had a size of nanoscale (∼20–50 nm) and were randomly oriented.
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