Effects of a hypercaloric diet on β‐cell responsivity in lean healthy men

Abstract

A positive energy balance resulting in weight gain in lean men induces hyperinsulinaemia, which is explained by a combined effect on insulin clearance and insulin secretion. Increased insulin secretion was related to insulin resistance-induced higher glucose concentrations but also to increased dynamic β-cell responsivity. Glucose sensitivity of the β-cell did not change. These early adaptations are completely reversible during a negative energy balance after loss of the gained weight.