Superantigens and Chronic Rhinosinusitis: Skewing of T-Cell Receptor Vβ-Distributions in Polyp-Derived CD4⁺ and CD8⁺ T Cells

Abstract

This study establishes evidence of S. aureus SAg-T-cell interactions in polyp lymphocytes of 35% of CRSwNP patients. Although these results are consistent with intranasal exposure of polyp lymphocytes to SAg's, additional study is necessary to establish the role of these toxins in disease pathogenesis.