Randomised clinical trial: gluten may cause depression in subjects with non‐coeliac gluten sensitivity – an exploratory clinical study

Abstract

Short-term exposure to gluten specifically induced current feelings of depression with no effect on other indices or on emotional disposition. Gluten-specific induction of gastrointestinal symptoms was not identified. Such findings might explain why patients with non-coeliac gluten sensitivity feel better on a gluten-free diet despite the continuation of gastrointestinal symptoms.