Association of <i>Nrf2</i> Polymorphism Haplotypes with Acute Lung Injury Phenotypes in Inbred Strains of Mice

Abstract

The results indicate significant influence of Nrf2 polymorphisms and haplotypes on gene function and hyperoxia susceptibility. Our findings further support Nrf2 as a genetic determinant in ALI pathogenesis and provide useful tools for investigators who use mouse strains classified by Nrf2 haplotypes to elucidate the role for Nrf2 in oxidative disorders.