Suppression of <scp>TRPM</scp>7 Inhibits Proliferation, Migration, and Invasion of Malignant Human Glioma Cells

Abstract

We demonstrate that human glioma cells express functional TRPM7 channel and that activation of this channel plays an important role in the proliferation, migration, and invasion of malignant glioma cells. TRPM7 channel may represent a novel and promising target for therapeutic intervention of malignant glioma.