Co-Crystallization in the Caffeine/Maleic Acid System: Lessons from Phase Equilibria

Abstract

Previous studies of the cocrystallizing system caffeine−maleic acid has shown the existence of 1:1 and 2:1 cocrystals together with a new polymorph of maleic acid. In this current work, we have attempted to rationalize this behavior through measurement of the binary and ternary phase diagrams.