Spectral Polarization Imaging of Human Prostate Cancer Tissue Using a Near-infrared Receptor-targeted Contrast Agent

Yeong‐Shiau Pu, W. B. Wang, G. C. Tang, F. Zeng, Samuel Achilefu, Jack H. Vitenson, Ihor S. Sawczuk, Solange Peters, Joseph M. Lombardo, R. R. Alfano

Technology in Cancer Research & Treatment · 2005 · 68 citations · 10 references

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Abstract

The Cypate-Bombesin Peptide Analogue Conjugate (Cybesin) was used as a prostate tumor receptor-targeted contrast agent. The absorption and fluorescence spectra of Cybesin were measured and shown to exist in the NIR tissue "optical window". The spectral polarization imaging of Cybesin-stained prostate cancerous and normal tissues shows that prostate cancerous tissue takes-up more Cybesin than that of prostate normal tissue, making Cybesin a potential marker of prostate cancer.

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