Ethnomedical Survey and Cytotoxic Activity of Medicinal Plant Extracts Used in Kohgiluyeh and Boyerahmad Province in Iran

Abstract

Abstract Methanol extracts of selected medicinal species used in Kohgiluyeh and Boyerahmad (Iran) were evaluated in vitro for their cytotoxic activity against MCF7, HepG2, MDBK, and A549 cells through MTT assay. The extract from Dorema aucheri demonstrated cytotoxicity with IC50 of 20.09 and 48.65μg.mL−1 against HepG2 and A549 cells, respectively, which was further fractionated and subjected to MTT assay. The results may support the non-cytotoxicity of most plant species used traditionally as natural remedies. Keywords: EthnobotanyethnopharmacologyMTT assay Acknowledgments The authors thank the contribution of the local healers of Kohgiluyeh and Boyerahmad, Iran, especially Miss Azar Ravangard, who participated in interviewing about natural remedies of the province.